The responsiveness of the elderly to different drugs is different. Some target organs are more sensitive to drugs and more effective, such as central nervous system drugs, anticoagulants, diuretics and antihypertensive drugs; some target organs are less sensitive to a few drugs and less effective, such as receptor agonists and blockers. The interaction between diseases and drugs may lead to the increase of adverse drug reactions.
The elderly should be familiar with the characteristics of various drugs and dosage forms, and choose safe drugs with good efficacy, small side effects and aiming at the disease. It is not allowed to choose drugs on their own or add or subtract the dosage of drugs at will. For the old people who are older, lighter and have poor physique, they should start from the “minimum dose”, i.e. according to the order of 1 / 5, 1 / 4, 1 / 3, 1 / 2, 2 / 3 and 3 / 4 of the “adult amount” in the drug manual. Generally, it is recommended to use half or 1 / 3 of the adult dose as the initial dose, and then observe the patient’s response and condition improvement, adjust and stabilize to a reasonable dose.
However, it should be noted that some oral drugs can not be broken or crushed, so it is necessary to read the instructions for medication thoroughly. For example, some enteric coated tablets, controlled-release tablets and sustained-release tablets, due to the special materials on the surface, can not be taken apart, except for the special scratches on the surface.
In a word, the individual difference of the elderly is large, and the dosage can vary several times, such as antipyretic and analgesic drugs, β – receptor blocker, etc., so it is suggested to carry out individualized drug administration, carry out drug testing purposefully, observe the effect and reaction of drug use carefully, and find out the rule of individual drug use. Elderly friends should actively cooperate with doctors to master the most reasonable dosage as soon as possible.