Weight loss medicine, the better the effect of first-class alternative?

Losing weight through drugs is undoubtedly a double-edged sword. Weight-loss drugs that are effective, safe, and non-rebound like the ads say have not yet been developed.

Obesity is treated as a disease, whether to use drugs to lose weight should follow the advice of a doctor. Generally speaking, only the BMI (height and body mass index, that is, the value obtained by dividing the weight in kilograms by the square of height in meters) is greater than 30, or greater than 27 and accompanied by other diseases such as hypertension, High blood lipids, diabetes, etc.), the doctor will recommend using drugs to lose weight. For the general overweight, the use of drugs to lose weight is not considered necessary, or the disadvantages outweigh the benefits.

The relationship between BMI and physical fitness and disease risk is slightly different in different populations. Asians generally have lower BMIs than Europe and the United States. In China, BMI is considered a reasonable value from 18.5 to 23.9, 24 to 27.9 is overweight, and 28 or more is obese.

Losing weight or maintaining a reasonable weight is very important for health, but losing weight through drugs is undoubtedly a double-edged sword. Weight-loss drugs that are effective, safe, and non-rebound like the ads say have not yet been developed. Many people who lose weight in order to be beautiful have far less BMI than recommended drugs. From a health point of view, a reasonable and healthy recipe plus moderate exercise is the most beneficial.

Taking medicine to inhibit fat absorption or damage the liver On August 24, 2009, the US Food and Drug Administration (FDA) announced the investigation of the side effects of the best-selling weight-loss drugs Alli and Xenical. In the past few years , the FDA has received reports of liver damage in 32 Ale or Xenical users.

AllAlli is the only over-the-counter weight loss drug approved by the FDA, and people can buy it freely. Xenical is a prescription version of Alai, which has twice the active ingredients of Alai, and can only be purchased with a doctor s prescription.

莱 The manufacturers of Allai and Xenical refuse to acknowledge that Allai can cause liver damage. They claim that Allai s safety is supported by more than one hundred clinical trials. The FDA has not yet determined that liver damage is directly related to weight loss, saying that it can be continued under the guidance of a doctor. However, questions about the safety of Alle and Xenical are far from over. Earlier this year the UK also started investigating its side effects.

Allai and Xenical s active ingredient is called orlistat and is a lipase inhibitor. It reduces calorie intake by interfering with fat digestion and inhibiting fat absorption, thereby achieving weight loss. Scientific papers have reported a loss of 2.9 kg for 6 to 12 months. However, while inhibiting fat absorption, the absorption of fat-soluble vitamins (such as vitamins A, D, E, K, etc.) is also inhibited. Common side effects include thinning, bloating, irregular bowel movements, abdominal pain, and indigestion.

As a drug, Orlistan s weight loss effect is obvious. Compared to the efficacy, these side effects can be accepted. However, if the findings prove that it can also damage the liver, the side effects are too great.

食 Appetite-controlling drugs can not be taken for a long time, there is another class of weight-loss drugs that suppress appetite by changing adrenaline. The most commonly used is phentermine. Phentermine s short-term weight loss effect is obvious. With proper lifestyle control, it can lose an average of 3.6 kg. Its most common side effects are dry mouth, headache, insomnia, nervousness, irritability, and constipation. On the one hand, these side effects limit its long-term use; on the other hand, long-term use will increase the body s tolerance, the effect will be reduced, and it will be prone to dependence and abuse. Phenylpropanolamine is also a drug of this type, which was approved for sale as an over-the -counter drug, but was later found to have the potential to cause hemorrhagic stroke in women and was cancelled.

There is also a class of weight loss drugs related to serotonin in the body. They affect the amount of food eaten over a period of time, increase the body s basal metabolism, and achieve weight loss by eat less and consume more . The FDA has approved the use of fenfluramine (Pondimin) and dexfenfluramine (dexfenfluramine, Redux), but because they have the risk of causing heart valve disease and pulmonary hypertension, manufacturers voluntarily cancelled both Products.

The FDA also approved the use of a drug called sibutramine for weight loss. It has the dual effect of changing adrenaline and serotonin, and the weight loss effect is considerable. After 12 months of treatment, reports of 4.2 to 4.5 kg loss have been reported . Another study reports that the effect of losing 4 kg can be maintained after two years. However, it can also cause dry mouth, constipation, insomnia, high blood pressure and heart rate, and palpitations.

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